翻訳と辞書 Words near each other ・ Transfer station ・ Transfer Station (Hudson County) ・ Transfer station (waste management) ・ Transfer switch ・ Transfer table ・ Transfer tax ・ Transfer technique ・ Transfer technique (drawing) ・ Transfer Walsh ・ Transfer window ・ Transfer zone ・ Transfer-appropriate processing ・ Transfer-based machine translation ・ Transfer-matrix method ・ Transfer-matrix method (optics) ・ Transfer-messenger RNA ・ Transferability ・ Transferable belief model ・ Transferable skill ・ Transferable skills analysis ・ Transferable utility ・ Transferase ・ Transference ・ Transference (album) ・ Transference (disambiguation) ・ Transference focused psychotherapy ・ Transference neurosis ・ TransferGo ・ TransferJet ・ Transfermarkt Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Transfer-messenger RNA ： ウィキペディア英語版 Transfer-messenger RNA Transfer-messenger RNA (abbreviated tmRNA, also known as 10Sa RNA and by its genetic name SsrA) is a bacterial RNA molecule with dual tRNA-like and messenger RNA-like properties. The tmRNA forms a ribonucleoprotein complex (tmRNP) together with Small Protein B (SmpB), Elongation Factor Tu (EF-Tu), and ribosomal protein S1. In ''trans''-translation, tmRNA and its associated proteins bind to bacterial ribosomes which have stalled in the middle of protein biosynthesis, for example when reaching the end of a messenger RNA which has lost its stop codon. The tmRNA is remarkably versatile: it recycles the stalled ribosome, adds a proteolysis-inducing tag to the unfinished polypeptide, and facilitates the degradation of the aberrant messenger RNA. In the majority of bacteria these functions are carried out by standard one-piece tmRNAs. In other bacterial species, a permuted ''ssrA'' gene produces a two-piece tmRNA in which two separate RNA chains are joined by base-pairing. ==Discovery of tmRNA and early work== tmRNA was first designated 10Sa RNA after a mixed “10S” electrophoretic fraction of ''Escherichia coli'' RNA was further resolved into tmRNA and the similarly-sized RNase P RNA (10Sb). The presence of pseudouridine in the mixed 10S RNA hinted that tmRNA has modified bases found also in tRNA. The similarity at the 3' end of tmRNA to the T stem-loop of tRNA was first recognized upon sequencing ''ssrA'' from ''Mycobacterium tuberculosis''. Subsequent sequence comparison revealed the full tRNA-like domain (TLD) formed by the 5' and 3' ends of tmRNA, including the acceptor stem with elements like those in alanine tRNA that promote its aminoacylation by alanine-tRNA ligase. It also revealed differences from tRNA: the anticodon arm is missing in tmRNA, and the D arm region is a loop without base pairs. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Transfer-messenger RNA」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.